Nutritional Therapy Research

Featured Research

Successful Dietary Therapy in Paediatric Crohn's Disease is Associated with Shifts in Bacterial Dysbiosis and Inflammatory Metabotype Towards Healthy Controls (CDED)

NTforIBD Comment: October 2022 Newsletter

Summary Excerpt: Successful dietary therapy induced correction of both compositional and functional dysbiosis. However, 12 weeks of diet was not enough to achieve complete correction of dysbiosis.

J Crohns Colitis. Published online September 15, 2022. doi: https://doi.org/10.1093/ecco-jcc/jjac105
Verburgt CM, et al.

Effect of the Crohn’s Disease Exclusion Diet (CDED) on the Fecal Calprotectin Level in Children with Active Crohn’s Disease (CDED)

NTforIBD Comment: October 2022 Newsletter

Summary Excerpt: In their conclusion, the authors wrote: “In the group under analysis, this nutritional intervention resulted in a significant decrease in FCP level and contributed to normalization of this parameter in one-third of patients, which is a similar or better result compared to pharmacological treatment.”

J Clin Med. 2022;11(14):4146. doi: https://doi.org/10.3390/jcm11144146
Matuszczyk M, et al.

Assessing Barriers to use of the Specific Carbohydrate Diet in Pediatric Inflammatory Bowel Disease: A Qualitative Study (SCD)

NTforIBD Comment: October 2022 Newsletter

Summary Excerpt: To our knowledge, this is the first study examining barriers to the SCD among pediatric IBD patients.

JPGN Reports. 2022;3(3):e239
Schwartz N., et al.

Perspectives on Specific Carbohydrate Diet Education from Inflammatory Bowel Disease Patients and Caregivers: A Needs Assessment (SCD)

NTforIBD Comment: October 2022 Newsletter

Summary Excerpt: Increasing educational content on the SCD to individuals, caregivers, and medical providers has the potential to improve adherence and sustainability on the SCD.

JPGN Reports. 2022;3(3):e222. doi: https://doi.org/10.1097/PG9.0000000000000222
Rivera, N. et al

Date Title Diets Authors Summary Excerpt Citation
Aug 2019 Crohn's Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial CDED, PEN Levine A et al CDED plus PEN was better tolerated than EEN in children with mild to moderate CD. Both diets were effective in inducing remission by week 6. The combination CDED plus PEN induced sustained remission in a significantly higher proportion of patients than EEN, and produced changes in the fecal microbiome associated with remission. These data support use of CDED plus PEN to induce remission in children with CD. Gastroenterology. 2019 Aug;157(2):440-450.e8. doi: 10.1053/j.gastro.2019.04.021. Epub 2019 Jun 4
Oct 2017 Diet to the Rescue: Cessation of Pharmacotherapy After Initiation of Exclusive Enteral Nutrition (EEN) Followed by Strict and Liberalized Specific Carbohydrate Diet (SCD) in Crohn's Disease EEN, SCD Nakayuenyongsuk W et al NA Dig Dis Sci. 2017 Oct;62(10):2686-2689. doi: 10.1007/s10620-016-4446-1.
Apr 2020 Dietary Therapies Induce Rapid Response and Remission in Pediatric Patients With Active Crohn's Disease CDED, EEN Sigall Boneh R et al For pediatric patients with active CD, dietary therapies (CDED and EEN) induce a rapid clinical response (by week 3). Identification of patients with and without a rapid response to diet might help identify those who, with compliance, will be in clinical remission by week 6 of the diet. Clin Gastroenterol Hepatol . 2020 Apr 14;S1542-3565(20)30487-0. doi: 10.1016/j.cgh.2020.04.006.
Oct 2017 Dietary Therapy With the Crohn's Disease Exclusion Diet Is a Successful Strategy for Induction of Remission in Children and Adults Failing Biological Therapy CDED Sigall-Boneh RS et al Dietary treatment combining PEN with the CDED may be a useful salvage regimen for patients failing biological therapy despite dose escalation. J Crohns Colitis , 11 (10), 1205-1212 2017 Oct 1
Jan 2022 Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study IBD-AID Olendzki B et al Consumption of prebiotics, probiotics, and beneficial foods correlated with increased abundance of Clostridia and Bacteroides, commonly depleted in IBD cohorts. We further show that specific foods categorized as prebiotics or adverse foods are correlated to levels of cytokines in serum (i.e., GM-CSF, IL-6, IL-8, TNF-alpha) that play a central role in IBD pathogenesis. Gut Microbes . Jan-Dec 2022;14(1):2046244. doi: 10.1080/19490976.2022.2046244.
Jul 2022 Effect of the Crohn’s Disease Exclusion Diet (CDED) on the Fecal Calprotectin Level in Children with Active Crohn’s Disease CDED Matuszczyk M, et al. In their conclusion, the authors wrote: “In the group under analysis, this nutritional intervention resulted in a significant decrease in FCP level and contributed to normalization of this parameter in one-third of patients, which is a similar or better result compared to pharmacological treatment.” J Clin Med. 2022;11(14):4146. doi: https://doi.org/10.3390/jcm11144146
Oct 2017 Effect of the Specific Carbohydrate Diet on Inflammatory Bowel Disease: A 5-Year Longitudinal Study SCD Chutkan R et al Our data confirms that the Specific Carbohydrate Diet is an effective long-term treatment for IBD that can result in improvement of symptoms, mucosal healing, and discontinuation of biologic and immunosuppressive medications. American Journal of Gastroenterology: October 2017 - Volume 112 - Issue - p S1479
Feb 2018 Effect of the Specific Carbohydrate Diet on the Microbiome of a Primary Sclerosing Cholangitis and Ulcerative Colitis Patient SCD Dubrovsky A and Kitts CL Not only were substantial changes in the fecal bacterial composition detectable within two weeks, but all UC symptoms were also controlled as early as one week following the start of the diet. Cureus. 2018 Feb 9;10(2):e2177. doi: 10.7759/cureus.2177.
Oct 2020 Effectiveness of Mediterranean Diet's Adherence in children with Inflammatory Bowel Diseases MED Strisciuglio C et al Children with IBD in remission have a sub-optimal food intake compared to HCs. MD seems to correlate to decreased intestinal inflammation. Nutrients . 2020 Oct 20;12(10):3206. doi: 10.3390/nu12103206.
May 2015 Efficacy of Concomitant Elemental Diet Therapy in Scheduled Infliximab Therapy in Patients With Crohn's Disease to Prevent Loss of Response EEN Kamata N et al Concomitant ED therapy is effective in maintaining scheduled IFX maintenance therapy in patients with luminal CD in order to prevent LOR. Dig Dis Sci , 60 (5), 1382-8 May 2015
Sep 2017 Efficacy of Exclusive Enteral Nutrition in Complicated Crohn's Disease EEN Yang Q et al EEN is effective in inducing early clinical remission, mucosal healing, promoting fistula closure and reducing the size of abscess in adult CD patients with complications. Scand J Gastroenterol , 52 (9), 995-1001 Sep 2017
Nov 2017 Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease AIP Konijeti GG et al Dietary elimination can improve symptoms and endoscopic inflammation in patients with IBD. Randomized controlled trials are warranted. Inflamm Bowel Dis , 23 (11), 2054-2060 Nov 2017

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