Publications Table

Date Title Diets Authors Summary Excerpt Citation
Oct 2014 Consensus Guidelines of ECCO/ESPGHAN on the Medical Management of Pediatric Crohn's Disease EEN Ruemmele FM et al The aim was to base on a thorough review of existing evidence a state of the art guidance on the medical treatment and long term management of children and adolescents with CD, with individualized treatment algorithms based on a benefit-risk analysis according to different clinical scenarios. In children and adolescents who did not have finished their growth, exclusive enteral nutrition (EEN) is the induction therapy of first choice due to its excellent safety profile, preferable over corticosteroids, which are equipotential to induce remission. J Crohns Colitis , 8 (10), 1179-207 Oct 2014
May 2015 Diet in the Pathogenesis and Treatment of Inflammatory Bowel Diseases EEN, CDED, SCD Lee D et al We review the roles of diet in the etiology and management of IBD, based on plausible mechanisms and clinical evidence. Researchers have learned much about the effects of diet on the mucosal immune system, epithelial function, and the intestinal microbiome; these findings could have significant practical implications. Controlled studies of patients receiving enteral nutrition and observations made from patients on exclusion diets have shown that components of whole foods can have deleterious effects for patients with IBD. Additionally, studies in animal models suggested that certain nutrients can reduce intestinal inflammation. Gastroenterology , 148 (6), 1087-106 May 2015
Jun 2015 Exclusive Enteral Nutrition in Children with Crohn’s Disease EEN Day AS and Lopez RN Exclusive enteral nutrition involves the use of a complete liquid diet, with the exclusion of normal dietary components for a defined period of time, as a therapeutic measure to induce remission in active Crohn's disease (CD). This very efficacious approach leads to high rates of remission, especially in children and adolescents newly diagnosed with CD. This intervention also results in mucosal healing, nutritional improvements and enhanced bone health. World J Gastroenterol , 21 (22), 6809-16 2015 Jun 14
Aug 2015 Diet and Inflammatory Bowel Disease SCD, IBD-AID Knight-Sepulveda K et al The role of diet has become very important in the prevention and treatment of IBD. Although there is a general lack of rigorous scientific evidence that demonstrates which diet is best for certain patients, several diets-such as the low-fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet; the specific carbohydrate diet; the anti-inflammatory diet; and the Paleolithic diet-have become popular. This article discusses the diets commonly recommended to IBD patients and reviews the supporting data. Gastroenterol Hepatol (N Y). 2015 Aug;11(8):511-20.
Jan 2016 The Role of Diet in Inflammatory Bowel Disease EEN, CDED, SCD Lewis JD When looking at medical therapy, there are some patients who are adequately managed with one medication, while others require multiple medications. In the future, there will likely be a subpopulation of patients with Crohn’s disease or ulcerative colitis whose inflammation can be controlled with a therapeutic diet. For other patients, dietary manipulation may be an ancillary therapy that can allow them to use less immunosuppression and still remain in remission. Finally, as with all medical therapies, there will almost certainly be a subset of the population in which dietary therapy is completely ineffective. Gastroenterol Hepatol (N Y). 2016 Jan; 12(1): 51–53.
Feb 2017 Diet as a Trigger or Therapy for Inflammatory Bowel Diseases SCD Lewis JD and Abreu MT We discuss current knowledge about popular diets, including the specific carbohydrate diet and diet low in fermentable oligo-, di-, and monosaccharides and polyols. We present findings from clinical and basic science studies to help gastroenterologists navigate diet as it relates to the management of IBD. Gastroenterology. 2017 Feb;152(2):398-414.e6. doi: 10.1053/j.gastro.2016.10.019. Epub 2016 Oct 25.
Mar 2017 Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease EEN Andersen V et al One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73-4.31, p < 0.01, OR 2.93; 95% CI: 1.66-5.17, p < 0.01, respectively) Nutrients , 9 (3) 2017 Mar 15
May 2017 The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review EEN MacLellan A et al While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients. Nutrients , 9 (5) 2017 May 1
Jun 2017 Specific Carbohydrate Diet for Inflammatory Bowel Disease — Learn About the SCD to Support Clients With IBD and How It Compares With Other Evidence-Based Nutritional Therapies SCD, EEN, PEN, IBD-AID Harris C Based on studies done thus far, the SCD appears to be an effective way to both establish and maintain remission for people with UC or CD. Both prospective and retrospective studies at different institutions with slightly different protocols have demonstrated benefits, and improvements have been observed in people of different ages and genders and with different locations and disease severity. Variants on the SCD, such as IBD-AID or "SCD-like" diets also may prove to be viable strategies—in fact, Seattle Children's Hospital is investigating the effectiveness of the SCD compared with a modified SCD with added foods, such as rice and oats, vs a more whole-foods based diet to see which strategy yields the best clinical results. Today's Dietitian Vol. 19, No. 6, P. 42
Aug 2017 Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention SCD, MED Aleksandrova K et al Other nutritional interventions or specific diets including the Specific Carbohydrate Diet (SCD), the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diet and, most recently, the Mediterranean diet have shown strong anti-inflammatory properties and show promise for improving disease symptoms. More work is required to evaluate the role of individual food compounds and complex nutritional interventions with the potential to decrease inflammation as a means of prevention and management of IBD. Nutrients. 2017 Aug 30;9(9). pii: E962. doi: 10.3390/nu9090962
Dec 2017 Dietary Therapies in Pediatric Inflammatory Bowel Disease: An Evolving Inflammatory Bowel Disease Paradigm EEN, PEN, SCD, CDED, IBD-AID Lane ER et al Recently, there has been growing interest and study of dietary interventions for induction and maintenance of remission. In addition to exclusive enteral nutrition, successes have been achieved with specific exclusion diets. This article evaluates current literature regarding the role of diet and nutrition in pathogenesis of disease, as well as the role of diet as primary therapy for pediatric IBD. Gastroenterol Clin North Am , 46 (4), 731-744 Dec 2017
Dec 2017 Diet as a Therapeutic Option for Adult Inflammatory Bowel Disease SCD, EEN Kakodkar S and Mutlu EA The literature on diet and IBD is reviewed with a particular focus on EEN, SCD, and low FODMAP diets. Lessons learned from the existing observations and strengths and shortcomings of existing data are presented. Gastroenterol Clin North Am. 2017 Dec;46(4):745-767. doi: 10.1016/j.gtc.2017.08.016

Nutritional Therapy for IBD

Improving the Care of Patients with Crohn’s Disease and Ulcerative Colitis through Diet