Publications Table

Date Title Diets Authors Summary Excerpt Citation
Sep 2018 Evolving Role of Diet in the Pathogenesis and Treatment of Inflammatory Bowel Diseases EEN, PEN, CDED, SCD, mSCD Levine A et al Uncontrolled clinical studies have demonstrated that various dietary therapies such as exclusive enteral nutrition and newly developed exclusion diets might be potent tools for induction of remission at disease onset, for patients failing biologic therapy, as a treatment for disease complications and in reducing the need for surgery. We review these advances from bench to bedside, along with the need for better clinical trials to support these interventions. Gut , 67 (9), 1726-1738 Sep 2018
Apr 2018 Enteral Nutrition in the Management of Pediatric and Adult Crohn's Disease EEN Hansen T and Duerksen DR In adults, EEN appears to be moderately beneficial for the induction of remission of CD; however, its use is understudied and underutilized. Stronger evidence is in place to support the use of EEN in pediatric CD with the added benefit of nutrition support and steroid-sparing therapy during the growth phase. Overall, EEN is an established therapy in inducing CD remission in the pediatric population while its role as primary therapy of adult Crohn's disease remains to be defined. Nutrients , 10 (5) 2018 Apr 26
Mar 2018 Reasoning Beyond the Potential Use of Exclusive Enteral Nutrition and Other Specified Diets in Children With Ulcerative Colitis EEN Shaoul R et al Although there is not yet definitive data illustrating a role for EEN in the management of active ulcerative colitis (UC), there are several lines of evidence that illustrate that dietary interventions may be helpful. In particular, the key mechanisms of the activity of EEN (namely, changes in the intestinal microflora in Crohn disease) are likely also relevant to UC. Furthermore, the use of EEN in pediatric UC patients may add to a better bone health. Prospective studies are now required to evaluate the role of EEN in UC in children. J Pediatr Gastroenterol Nutr , 66 (3), 378-382 Mar 2018
Dec 2017 Dietary Therapies in Pediatric Inflammatory Bowel Disease: An Evolving Inflammatory Bowel Disease Paradigm EEN, PEN, SCD, CDED, IBD-AID Lane ER et al Recently, there has been growing interest and study of dietary interventions for induction and maintenance of remission. In addition to exclusive enteral nutrition, successes have been achieved with specific exclusion diets. This article evaluates current literature regarding the role of diet and nutrition in pathogenesis of disease, as well as the role of diet as primary therapy for pediatric IBD. Gastroenterol Clin North Am , 46 (4), 731-744 Dec 2017
Dec 2017 Diet as a Therapeutic Option for Adult Inflammatory Bowel Disease SCD, EEN Kakodkar S and Mutlu EA The literature on diet and IBD is reviewed with a particular focus on EEN, SCD, and low FODMAP diets. Lessons learned from the existing observations and strengths and shortcomings of existing data are presented. Gastroenterol Clin North Am. 2017 Dec;46(4):745-767. doi: 10.1016/j.gtc.2017.08.016
Aug 2017 Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention SCD, MD Aleksandrova K et al Other nutritional interventions or specific diets including the Specific Carbohydrate Diet (SCD), the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diet and, most recently, the Mediterranean diet have shown strong anti-inflammatory properties and show promise for improving disease symptoms. More work is required to evaluate the role of individual food compounds and complex nutritional interventions with the potential to decrease inflammation as a means of prevention and management of IBD. Nutrients. 2017 Aug 30;9(9). pii: E962. doi: 10.3390/nu9090962
Jun 2017 Specific Carbohydrate Diet for Inflammatory Bowel Disease — Learn About the SCD to Support Clients With IBD and How It Compares With Other Evidence-Based Nutritional Therapies SCD, EEN, PEN, IBD-AID Harris C Based on studies done thus far, the SCD appears to be an effective way to both establish and maintain remission for people with UC or CD. Both prospective and retrospective studies at different institutions with slightly different protocols have demonstrated benefits, and improvements have been observed in people of different ages and genders and with different locations and disease severity. Variants on the SCD, such as IBD-AID or "SCD-like" diets also may prove to be viable strategies—in fact, Seattle Children's Hospital is investigating the effectiveness of the SCD compared with a modified SCD with added foods, such as rice and oats, vs a more whole-foods based diet to see which strategy yields the best clinical results. Today's Dietitian Vol. 19, No. 6, P. 42
May 2017 The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn’s Disease: A Review EEN MacLellan A et al While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients. Nutrients , 9 (5) 2017 May 1
Mar 2017 Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease EEN Andersen V et al One small prospective study on diet and anti-TNF treatment in 56 patients with CD found similar remission rates after 56 weeks among 32 patients with good compliance that received concomitant enteral nutrition and 24 with poor compliance that had no dietary restrictions (78% versus 67%, p = 0.51). A meta-analysis of 295 patients found higher odds of achieving clinical remission and remaining in clinical remission among patients on combination therapy with specialised enteral nutrition and Infliximab (IFX) compared with IFX monotherapy (OR 2.73; 95% CI: 1.73-4.31, p < 0.01, OR 2.93; 95% CI: 1.66-5.17, p < 0.01, respectively) Nutrients , 9 (3) 2017 Mar 15
Feb 2017 Diet as a Trigger or Therapy for Inflammatory Bowel Diseases SCD Lewis JD and Abreu MT We discuss current knowledge about popular diets, including the specific carbohydrate diet and diet low in fermentable oligo-, di-, and monosaccharides and polyols. We present findings from clinical and basic science studies to help gastroenterologists navigate diet as it relates to the management of IBD. Gastroenterology. 2017 Feb;152(2):398-414.e6. doi: 10.1053/j.gastro.2016.10.019. Epub 2016 Oct 25.
Jan 2016 The Role of Diet in Inflammatory Bowel Disease EEN, CDED, SCD Lewis JD When looking at medical therapy, there are some patients who are adequately managed with one medication, while others require multiple medications. In the future, there will likely be a subpopulation of patients with Crohn’s disease or ulcerative colitis whose inflammation can be controlled with a therapeutic diet. For other patients, dietary manipulation may be an ancillary therapy that can allow them to use less immunosuppression and still remain in remission. Finally, as with all medical therapies, there will almost certainly be a subset of the population in which dietary therapy is completely ineffective. Gastroenterol Hepatol (N Y). 2016 Jan; 12(1): 51–53.
Aug 2015 Diet and Inflammatory Bowel Disease SCD, IBD-AID Knight-Sepulveda K et al The role of diet has become very important in the prevention and treatment of IBD. Although there is a general lack of rigorous scientific evidence that demonstrates which diet is best for certain patients, several diets-such as the low-fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet; the specific carbohydrate diet; the anti-inflammatory diet; and the Paleolithic diet-have become popular. This article discusses the diets commonly recommended to IBD patients and reviews the supporting data. Gastroenterol Hepatol (N Y). 2015 Aug;11(8):511-20.