Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis
In a cross-over study of patients with UC in remission, we found that a catered LFD or iSAD were each well tolerated and increased quality of life. However, the LFD decreased markers of inflammation and reduced intestinal dysbiosis in fecal samples. Dietary interventions therefore might benefit patients with UC in remission.
Clin Gastroenterol Hepatol . 2020 May 20;S1542-3565(20)30685-6. doi: 10.1016/j.cgh.2020.05.026
Authors: Fritsch J et al
P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn’s disease patients who adhered to the CD-TREAT diet and responded by calprotectin.
Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults and children with active Crohn’s disease (CD); particularly in patients who adhere to the diet. Here we describe changes in faecal microbiome parameters during therapy with CD-TREAT and explore these changes against adherence.
Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i513–i515, https://doi.org/10.1093/ecco-jcc/jjac190.0510
Authors: Svolos V., et al.
Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome
In this review, the authors look at the increasing number of studies investigating the role the microbiome and other biomes play in pediatric patients with IBD, particularly changes associated with IBD, varying disease states, and therapeutics.
Fitzgerald, R.S., Sanderson, I.R. & Claesson, M.J. Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome. Microb Ecol (2021). https://doi.org/10.1007/s00248-021-01697-9
Authors: Fitzgerald RS et al
Perioperative Dietary Therapy in Inflammatory Bowel Disease
Perioperative dietary therapy improves the outcomes of IBD patients who undergo a surgical procedure. This topical review shares interdisciplinary expertise and provides guidance to optimise the outcomes of patients with Crohn's disease and ulcerative colitis. taking advantage of contemporary nutrition science.
J Crohns Colitis . 2020 May 21;14(4):431-444. doi: 10.1093/ecco-jcc/jjz160.
Authors: Adamina M et al
Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study
Pilot data indicate that promotion of both zinc intake and a Japanese diet rich in n-3 fatty acids may help induce clinical remission in patients with mild active UC. Nonetheless, large-scale randomized controlled trials are required to validate our findings.
Journal of Clinical Biochemistry and Nutrition, 2023, Volume 72, Issue 1, Pages 82-88,
Authors: Miyaguchi, K. et al.
Photo Credit: Kolpakova Svetlana/Shutterstock
The Effects of Commonly Consumed Dietary Fibres on the Gut Microbiome and Its Fibre Fermentative Capacity in Adults with Inflammatory Bowel Disease in Remission
Despite extensive microbial dysbiosis, patients with IBD have a similar capacity to ferment fibre and release SCFA as HC. Fibre supplementation alone may be unlikely to restore to a healthy status the compositional shifts characteristic of the IBD microbiome.
Nutrients 2022, 14(5), 1053; https://doi.org/10.3390/nu14051053
Authors: Gerasimidis, K
The Microbiota in Inflammatory Bowel Disease: Current and Therapeutic Insights
This review will characterize the factors involved in the development of the intestinal microbiome and will describe the typical alterations in the microbiota that are characteristic of inflammatory bowel disease. Additionally, this manuscript will summarize the early but promising literature on the role of the gut microbiota in the pathogenesis of inflammatory bowel disease with implications for utilizing this data for diagnostic or therapeutic application in the clinical management of patients with these diseases.
J Inflamm Res , 10, 63-73 2017 Jun 10 eCollection 2017
Authors: Lane ER et al
The Role of Precision Nutrition in the Modulation of Microbial Composition and Function in People with Inflammatory Bowel Disease
Authors discuss dietary patterns and their influence on the structure and function of the gut microbiome. They also discuss potential of innovative dietary strategies and future development of precision nutrition.
Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00097-2. doi:10.1016/S2468-1253(21)00097-2
Authors: Sasson AN, Ingram RJM, et al
The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions
We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD), involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each of these physiological components (dysbiosis, leaky gut, and inflammation) contributes in a mutually interdependent manner to IBD onset and exacerbation. Genetic and environmental risk factors lead to disruption of gut homeostasis: genetic risks predominantly affect the immune system, environmental risks predominantly affect the microbiota, and both affect barrier function.
Therap Adv Gastroenterol . 2016 Jul;9(4):606-25. doi: 10.1177/1756283X16644242. Epub 2016 Apr 19.
Authors: Vindigni SM et al
The microbiome and inflammatory bowel disease
In this review we will discuss the role of the gut microbiome in patients with IBD; our focus will be on human studies.
J Allergy Clin Immunol Pract. 2020 Jan;145(1)16-27. doi:10.1016/j.jaci.2019.11.003
Authors: Glassner KL et al
To Fiber or Not to Fiber: The Swinging Pendulum of Fiber Supplementation in Patients with Inflammatory Bowel Disease
This review describes dietary fibers and their mechanism of action within the microbiome, details novel fiber sources, including resistant starches and polyphenols, and concludes with potential future directions in fiber research, including the move toward precision nutrition.
Nutrients 2023, 15(5), 1080; https://doi.org/10.3390/nu15051080
Authors: Haskey N. et al.
Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients
Inflammatory bowel diseases are overall beneficially impacted by dietary fibers that are fermented by colonic microbes. Unfermented dietary β-fructan fibers induced proinflammatory cytokines in a subset of inflammatory bowel disease patient samples, via activation of the NLRP3 and TLR2 pathways; inflammation was reduced via fermentation by microbes.
Gastroenterology, 2023. https://doi.org/10.1053/j.gastro.2022.09.034
Authors: Armstrong H. et al.
