Related Research

A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares

In an analysis of data from the FACES trial, we found that among patients with CD in remission, level of red and processed meat consumption was not associated with time to symptomatic relapse.

Gastroenterology . 2019 Jul;157(1):128-136.e5. doi: 10.1053/j.gastro.2019.03.015. Epub 2019 Mar 11.

Authors: Albenberg L et al

• Go To Study

Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os

Here, we review the literature for dietary considerations during hospitalizations and acute settings, as well as upon discharge. Patients with IBD benefit from screening and nutritional support for malnutrition and nutritional deficiencies. Enteral nutrition and exclusion diets are promising as induction and maintenance therapies, but no specific recommendations during hospitalization for adult patients are available currently. There are very few reasons to enforce bowel rest or clear liquids other than bowel obstruction, uncontrolled sepsis, or need for urgent or emergent surgery; most patients—including many with penetrating or stricturing disease—benefit from feeding in whichever capacity is tolerated, with enteral and parenteral nutrition used as needed to reach nutritional goals.

Crohn's & Colitis 360, Volume 2, Issue 4, October 2020, otaa059

Authors: Palchaudhuri S et al

• Go To Study

Diet and Microbiota in Inflammatory Bowel Disease: The Gut in Disharmony

Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects.

World J Gastroenterol , 23 (12), 2124-2140 2017 Mar 28

Authors: Rapozo DCM et al

• Go To Study

Diet, Gut Microbiome and Epigenetics: Emerging Links With Inflammatory Bowel Diseases and Prospects for Management and Prevention

Other nutritional interventions or specific diets including the Specific Carbohydrate Diet (SCD), the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diet and, most recently, the Mediterranean diet have shown strong anti-inflammatory properties and show promise for improving disease symptoms. More work is required to evaluate the role of individual food compounds and complex nutritional interventions with the potential to decrease inflammation as a means of prevention and management of IBD.

Nutrients , 9 (9) 2017 Aug 30

Authors: Aleksandrova K et al

• Go To Study

Photo Credit: Apichatn21/Shutterstock 

Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study

In conclusion, we demonstrate that the IBD-AID can favor bacteria commonly depleted in IBD patients which are key for maintaining immune tolerance and homeostasis in the gut via SCFA production. We demonstrated that foods encouraged/discouraged by the IBD-AID are linked to modulation of the immune tone.

Gut Microbes. 2022 Jan-Dec;14(1):2046244. doi: 10.1080/19490976.2022.2046244.

Authors: Olendzki, B

• Go To Study

Food and the Gut Microbiota in IBD: A Critical Connection

Recent studies have demonstrated an association between the diet and the human microbiome. Because the development of a 'dysbiotic' microbiota is thought to be involved in the pathogenesis of IBD, diet is being investigated as an important etiologic factor.

Curr Opin Gastroenterol , 28 (4), 314-20 Jul 2012

Authors: Albenberg LG et al

• Go To Study

Gut Microbiome Structure and Metabolic Activity in Inflammatory Bowel Disease

Our findings thus provide an improved understanding of perturbations of the microbiome-metabolome interface in IBD, including identification of many potential diagnostic and therapeutic targets.

Nat Microbiol . 2019 Feb;4(2):293-305. doi: 10.1038/s41564-018-0306-4. Epub 2018 Dec 10.

Authors: Franzosa EA et al

• Go To Study

Gut-Microbiota-Targeted Diets Modulate Human Immune Status

Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit.

Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019

Authors: Wastyk H et al

• Go To Study

Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease

Dietary therapy had independent and rapid effects on microbiota composition distinct from other stressor-induced changes and effectively reduced inflammation. These findings reveal that dysbiosis results from independent effects of inflammation, diet, and antibiotics and shed light on Crohn disease treatments.

Cell Host Microbe , 18 (4), 489-500 2015 Oct 14

Authors: Lewis JD et al

• Go To Study

Long-term Dietary Patterns are Associated with Pro-Inflammatory and Anti-Inflammatory Features of the Gut Microbiome

Authors identify dietary patterns that consistently correlate with groups of bacteria with shared functional roles in health and disease. Specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects, proposing a microbial mechanism for anti-inflammatory dietary effects

Gut. 2021;70(7):1287-1298. doi:10.1136/gutjnl-2020-322670

Authors: Bolte L et al

• Go To Study

Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis

In a cross-over study of patients with UC in remission, we found that a catered LFD or iSAD were each well tolerated and increased quality of life. However, the LFD decreased markers of inflammation and reduced intestinal dysbiosis in fecal samples. Dietary interventions therefore might benefit patients with UC in remission.

Clin Gastroenterol Hepatol . 2020 May 20;S1542-3565(20)30685-6. doi: 10.1016/j.cgh.2020.05.026

Authors: Fritsch J et al

• Go To Study

P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn’s disease patients who adhered to the CD-TREAT diet and responded by calprotectin.

Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults and children with active Crohn’s disease (CD); particularly in patients who adhere to the diet. Here we describe changes in faecal microbiome parameters during therapy with CD-TREAT and explore these changes against adherence.

Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i513–i515, https://doi.org/10.1093/ecco-jcc/jjac190.0510

Authors: Svolos V., et al.

• Go To Study