Related Research

A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares

In an analysis of data from the FACES trial, we found that among patients with CD in remission, level of red and processed meat consumption was not associated with time to symptomatic relapse.

Gastroenterology . 2019 Jul;157(1):128-136.e5. doi: 10.1053/j.gastro.2019.03.015. Epub 2019 Mar 11.

Authors: Albenberg L et al

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Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os

Here, we review the literature for dietary considerations during hospitalizations and acute settings, as well as upon discharge. Patients with IBD benefit from screening and nutritional support for malnutrition and nutritional deficiencies. Enteral nutrition and exclusion diets are promising as induction and maintenance therapies, but no specific recommendations during hospitalization for adult patients are available currently. There are very few reasons to enforce bowel rest or clear liquids other than bowel obstruction, uncontrolled sepsis, or need for urgent or emergent surgery; most patients—including many with penetrating or stricturing disease—benefit from feeding in whichever capacity is tolerated, with enteral and parenteral nutrition used as needed to reach nutritional goals.

Crohn's & Colitis 360, Volume 2, Issue 4, October 2020, otaa059

Authors: Palchaudhuri S et al

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Diet and Microbiota in Inflammatory Bowel Disease: The Gut in Disharmony

Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects.

World J Gastroenterol , 23 (12), 2124-2140 2017 Mar 28

Authors: Rapozo DCM et al

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Diet, Gut Microbiome and Epigenetics: Emerging Links With Inflammatory Bowel Diseases and Prospects for Management and Prevention

Other nutritional interventions or specific diets including the Specific Carbohydrate Diet (SCD), the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diet and, most recently, the Mediterranean diet have shown strong anti-inflammatory properties and show promise for improving disease symptoms. More work is required to evaluate the role of individual food compounds and complex nutritional interventions with the potential to decrease inflammation as a means of prevention and management of IBD.

Nutrients , 9 (9) 2017 Aug 30

Authors: Aleksandrova K et al

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Photo Credit: Apichatn21/Shutterstock 

Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study

In conclusion, we demonstrate that the IBD-AID can favor bacteria commonly depleted in IBD patients which are key for maintaining immune tolerance and homeostasis in the gut via SCFA production. We demonstrated that foods encouraged/discouraged by the IBD-AID are linked to modulation of the immune tone.

Gut Microbes. 2022 Jan-Dec;14(1):2046244. doi: 10.1080/19490976.2022.2046244.

Authors: Olendzki, B

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Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study

In addition to their direct effects on bacterial growth, polysorbate 80 and/or carboxymethylcellulose can drive profound changes in the CD mucosa-associated microbiota via niche expansion of Proteus and/or Veillonellaceae – both implicated in early Crohn’s disease recurrence. These studies on the interaction of food additives with the enteric microbiota provide a basis for dietary management in Crohn’s disease.

Gut Microbes, 15:1. doi: 10.1080/19490976.2023.2172670

Authors: Loayza JJJ, et al.

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Food and the Gut Microbiota in IBD: A Critical Connection

Recent studies have demonstrated an association between the diet and the human microbiome. Because the development of a 'dysbiotic' microbiota is thought to be involved in the pathogenesis of IBD, diet is being investigated as an important etiologic factor.

Curr Opin Gastroenterol , 28 (4), 314-20 Jul 2012

Authors: Albenberg LG et al

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Gut Microbiome Structure and Metabolic Activity in Inflammatory Bowel Disease

Our findings thus provide an improved understanding of perturbations of the microbiome-metabolome interface in IBD, including identification of many potential diagnostic and therapeutic targets.

Nat Microbiol . 2019 Feb;4(2):293-305. doi: 10.1038/s41564-018-0306-4. Epub 2018 Dec 10.

Authors: Franzosa EA et al

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Gut-Microbiota-Targeted Diets Modulate Human Immune Status

Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit.

Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019

Authors: Wastyk H et al

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Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease

Sorbitol and sorbitol utilization in the infecting C difficile strain play major roles for the pathogenesis and epidemiology of CDI in patients with IBD. CDI in patients with IBD may thus be avoided or improved by elimination of dietary sorbitol or suppression of host-derived sorbitol production.

Gastroenterology, 2023, , ISSN 0016-5085, https://doi.org/10.1053/j.gastro.2023.02.046.

Authors: Yang Z. et al.

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Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease

Dietary therapy had independent and rapid effects on microbiota composition distinct from other stressor-induced changes and effectively reduced inflammation. These findings reveal that dysbiosis results from independent effects of inflammation, diet, and antibiotics and shed light on Crohn disease treatments.

Cell Host Microbe , 18 (4), 489-500 2015 Oct 14

Authors: Lewis JD et al

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Long-term Dietary Patterns are Associated with Pro-Inflammatory and Anti-Inflammatory Features of the Gut Microbiome

Authors identify dietary patterns that consistently correlate with groups of bacteria with shared functional roles in health and disease. Specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects, proposing a microbial mechanism for anti-inflammatory dietary effects

Gut. 2021;70(7):1287-1298. doi:10.1136/gutjnl-2020-322670

Authors: Bolte L et al

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