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Date Title Categories Authors Summary Excerpt Citation
Mar 2023 Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease Food and Supplements Yang Z. et al. Sorbitol and sorbitol utilization in the infecting C difficile strain play major roles for the pathogenesis and epidemiology of CDI in patients with IBD. CDI in patients with IBD may thus be avoided or improved by elimination of dietary sorbitol or suppression of host-derived sorbitol production. Gastroenterology, 2023, , ISSN 0016-5085,
Jul 2021 Gut-Microbiota-Targeted Diets Modulate Human Immune Status Microbiome Wastyk H et al Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit. Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019
Jul 2016 The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions Microbiome Vindigni SM et al We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD), involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each of these physiological components (dysbiosis, leaky gut, and inflammation) contributes in a mutually interdependent manner to IBD onset and exacerbation. Genetic and environmental risk factors lead to disruption of gut homeostasis: genetic risks predominantly affect the immune system, environmental risks predominantly affect the microbiota, and both affect barrier function. Therap Adv Gastroenterol . 2016 Jul;9(4):606-25. doi: 10.1177/1756283X16644242. Epub 2016 Apr 19.
Jan 2023 P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn’s disease patients who adhered to the CD-TREAT diet and responded by calprotectin. Microbiome Svolos V., et al. Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults and children with active Crohn’s disease (CD); particularly in patients who adhere to the diet. Here we describe changes in faecal microbiome parameters during therapy with CD-TREAT and explore these changes against adherence. Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i513–i515,
Jul 2021 The Role of Precision Nutrition in the Modulation of Microbial Composition and Function in People with Inflammatory Bowel Disease Microbiome Sasson AN, Ingram RJM, et al Authors discuss dietary patterns and their influence on the structure and function of the gut microbiome. They also discuss potential of innovative dietary strategies and future development of precision nutrition. Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00097-2. doi:10.1016/S2468-1253(21)00097-2
Mar 2017 Diet and Microbiota in Inflammatory Bowel Disease: The Gut in Disharmony Microbiome Rapozo DCM et al Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects. World J Gastroenterol , 23 (12), 2124-2140 2017 Mar 28
Oct 2020 Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os Perioperative NT Palchaudhuri S et al Here, we review the literature for dietary considerations during hospitalizations and acute settings, as well as upon discharge. Patients with IBD benefit from screening and nutritional support for malnutrition and nutritional deficiencies. Enteral nutrition and exclusion diets are promising as induction and maintenance therapies, but no specific recommendations during hospitalization for adult patients are available currently. There are very few reasons to enforce bowel rest or clear liquids other than bowel obstruction, uncontrolled sepsis, or need for urgent or emergent surgery; most patients—including many with penetrating or stricturing disease—benefit from feeding in whichever capacity is tolerated, with enteral and parenteral nutrition used as needed to reach nutritional goals. Crohn's & Colitis 360, Volume 2, Issue 4, October 2020, otaa059
Jan 2022 Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study Microbiome Olendzki, B In conclusion, we demonstrate that the IBD-AID can favor bacteria commonly depleted in IBD patients which are key for maintaining immune tolerance and homeostasis in the gut via SCFA production. We demonstrated that foods encouraged/discouraged by the IBD-AID are linked to modulation of the immune tone. Gut Microbes. 2022 Jan-Dec;14(1):2046244. doi: 10.1080/19490976.2022.2046244.
Nov 2022 Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study Food and Supplements Miyaguchi, K. et al. Pilot data indicate that promotion of both zinc intake and a Japanese diet rich in n-3 fatty acids may help induce clinical remission in patients with mild active UC. Nonetheless, large-scale randomized controlled trials are required to validate our findings. Journal of Clinical Biochemistry and Nutrition, 2023, Volume 72, Issue 1, Pages 82-88,
Feb 2023 Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study Microbiome Loayza JJJ, et al. In addition to their direct effects on bacterial growth, polysorbate 80 and/or carboxymethylcellulose can drive profound changes in the CD mucosa-associated microbiota via niche expansion of Proteus and/or Veillonellaceae – both implicated in early Crohn’s disease recurrence. These studies on the interaction of food additives with the enteric microbiota provide a basis for dietary management in Crohn’s disease. Gut Microbes, 15:1. doi: 10.1080/19490976.2023.2172670
Oct 2015 Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease Microbiome Lewis JD et al Dietary therapy had independent and rapid effects on microbiota composition distinct from other stressor-induced changes and effectively reduced inflammation. These findings reveal that dysbiosis results from independent effects of inflammation, diet, and antibiotics and shed light on Crohn disease treatments. Cell Host Microbe , 18 (4), 489-500 2015 Oct 14
Jun 2017 The Microbiota in Inflammatory Bowel Disease: Current and Therapeutic Insights Microbiome Lane ER et al This review will characterize the factors involved in the development of the intestinal microbiome and will describe the typical alterations in the microbiota that are characteristic of inflammatory bowel disease. Additionally, this manuscript will summarize the early but promising literature on the role of the gut microbiota in the pathogenesis of inflammatory bowel disease with implications for utilizing this data for diagnostic or therapeutic application in the clinical management of patients with these diseases. J Inflamm Res , 10, 63-73 2017 Jun 10 eCollection 2017

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