Related Research

Gut-Microbiota-Targeted Diets Modulate Human Immune Status

Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit.

Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019

Authors: Wastyk H et al

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The intestinal microbiome, barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions

We discuss the tripartite pathophysiological circuit of inflammatory bowel disease (IBD), involving the intestinal microbiota, barrier function, and immune system. Dysfunction in each of these physiological components (dysbiosis, leaky gut, and inflammation) contributes in a mutually interdependent manner to IBD onset and exacerbation. Genetic and environmental risk factors lead to disruption of gut homeostasis: genetic risks predominantly affect the immune system, environmental risks predominantly affect the microbiota, and both affect barrier function.

Therap Adv Gastroenterol . 2016 Jul;9(4):606-25. doi: 10.1177/1756283X16644242. Epub 2016 Apr 19.

Authors: Vindigni SM et al

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The Role of Precision Nutrition in the Modulation of Microbial Composition and Function in People with Inflammatory Bowel Disease

Authors discuss dietary patterns and their influence on the structure and function of the gut microbiome. They also discuss potential of innovative dietary strategies and future development of precision nutrition.

Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00097-2. doi:10.1016/S2468-1253(21)00097-2

Authors: Sasson AN, Ingram RJM, et al

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Diet and Microbiota in Inflammatory Bowel Disease: The Gut in Disharmony

Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects.

World J Gastroenterol , 23 (12), 2124-2140 2017 Mar 28

Authors: Rapozo DCM et al

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Photo Credit: Apichatn21/Shutterstock 

Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study

In conclusion, we demonstrate that the IBD-AID can favor bacteria commonly depleted in IBD patients which are key for maintaining immune tolerance and homeostasis in the gut via SCFA production. We demonstrated that foods encouraged/discouraged by the IBD-AID are linked to modulation of the immune tone.

Gut Microbes. 2022 Jan-Dec;14(1):2046244. doi: 10.1080/19490976.2022.2046244.

Authors: Olendzki, B

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Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease

Dietary therapy had independent and rapid effects on microbiota composition distinct from other stressor-induced changes and effectively reduced inflammation. These findings reveal that dysbiosis results from independent effects of inflammation, diet, and antibiotics and shed light on Crohn disease treatments.

Cell Host Microbe , 18 (4), 489-500 2015 Oct 14

Authors: Lewis JD et al

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The Microbiota in Inflammatory Bowel Disease: Current and Therapeutic Insights

This review will characterize the factors involved in the development of the intestinal microbiome and will describe the typical alterations in the microbiota that are characteristic of inflammatory bowel disease. Additionally, this manuscript will summarize the early but promising literature on the role of the gut microbiota in the pathogenesis of inflammatory bowel disease with implications for utilizing this data for diagnostic or therapeutic application in the clinical management of patients with these diseases.

J Inflamm Res , 10, 63-73 2017 Jun 10 eCollection 2017

Authors: Lane ER et al

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The microbiome and inflammatory bowel disease

In this review we will discuss the role of the gut microbiome in patients with IBD; our focus will be on human studies.

J Allergy Clin Immunol Pract. 2020 Jan;145(1)16-27. doi:10.1016/j.jaci.2019.11.003

Authors: Glassner KL et al

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Photo Credit: Kolpakova Svetlana/Shutterstock 

The Effects of Commonly Consumed Dietary Fibres on the Gut Microbiome and Its Fibre Fermentative Capacity in Adults with Inflammatory Bowel Disease in Remission

Despite extensive microbial dysbiosis, patients with IBD have a similar capacity to ferment fibre and release SCFA as HC. Fibre supplementation alone may be unlikely to restore to a healthy status the compositional shifts characteristic of the IBD microbiome.

Nutrients 2022, 14(5), 1053; https://doi.org/10.3390/nu14051053

Authors: Gerasimidis, K

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Gut Microbiome Structure and Metabolic Activity in Inflammatory Bowel Disease

Our findings thus provide an improved understanding of perturbations of the microbiome-metabolome interface in IBD, including identification of many potential diagnostic and therapeutic targets.

Nat Microbiol . 2019 Feb;4(2):293-305. doi: 10.1038/s41564-018-0306-4. Epub 2018 Dec 10.

Authors: Franzosa EA et al

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Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome

In this review, the authors look at the increasing number of studies investigating the role the microbiome and other biomes play in pediatric patients with IBD, particularly changes associated with IBD, varying disease states, and therapeutics.

Fitzgerald, R.S., Sanderson, I.R. & Claesson, M.J. Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome. Microb Ecol (2021). https://doi.org/10.1007/s00248-021-01697-9

Authors: Fitzgerald RS et al

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Long-term Dietary Patterns are Associated with Pro-Inflammatory and Anti-Inflammatory Features of the Gut Microbiome

Authors identify dietary patterns that consistently correlate with groups of bacteria with shared functional roles in health and disease. Specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects, proposing a microbial mechanism for anti-inflammatory dietary effects

Gut. 2021;70(7):1287-1298. doi:10.1136/gutjnl-2020-322670

Authors: Bolte L et al

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