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Date Title Categories Authors Summary Excerpt Citation
Mar 2023 Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease Food and Supplements Yang Z. et al. Sorbitol and sorbitol utilization in the infecting C difficile strain play major roles for the pathogenesis and epidemiology of CDI in patients with IBD. CDI in patients with IBD may thus be avoided or improved by elimination of dietary sorbitol or suppression of host-derived sorbitol production. Gastroenterology, 2023, , ISSN 0016-5085,
Feb 2023 Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn’s disease. The ENIGMA study Microbiome Loayza JJJ, et al. In addition to their direct effects on bacterial growth, polysorbate 80 and/or carboxymethylcellulose can drive profound changes in the CD mucosa-associated microbiota via niche expansion of Proteus and/or Veillonellaceae – both implicated in early Crohn’s disease recurrence. These studies on the interaction of food additives with the enteric microbiota provide a basis for dietary management in Crohn’s disease. Gut Microbes, 15:1. doi: 10.1080/19490976.2023.2172670
Feb 2023 To Fiber or Not to Fiber: The Swinging Pendulum of Fiber Supplementation in Patients with Inflammatory Bowel Disease Microbiome Haskey N. et al. This review describes dietary fibers and their mechanism of action within the microbiome, details novel fiber sources, including resistant starches and polyphenols, and concludes with potential future directions in fiber research, including the move toward precision nutrition. Nutrients 2023, 15(5), 1080;
Jan 2023 P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn’s disease patients who adhered to the CD-TREAT diet and responded by calprotectin. Microbiome Svolos V., et al. Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults and children with active Crohn’s disease (CD); particularly in patients who adhere to the diet. Here we describe changes in faecal microbiome parameters during therapy with CD-TREAT and explore these changes against adherence. Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i513–i515,
Nov 2022 Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study Food and Supplements Miyaguchi, K. et al. Pilot data indicate that promotion of both zinc intake and a Japanese diet rich in n-3 fatty acids may help induce clinical remission in patients with mild active UC. Nonetheless, large-scale randomized controlled trials are required to validate our findings. Journal of Clinical Biochemistry and Nutrition, 2023, Volume 72, Issue 1, Pages 82-88,
Sep 2022 Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients Microbiome Armstrong H. et al. Inflammatory bowel diseases are overall beneficially impacted by dietary fibers that are fermented by colonic microbes. Unfermented dietary β-fructan fibers induced proinflammatory cytokines in a subset of inflammatory bowel disease patient samples, via activation of the NLRP3 and TLR2 pathways; inflammation was reduced via fermentation by microbes. Gastroenterology, 2023.
Mar 2022 The Effects of Commonly Consumed Dietary Fibres on the Gut Microbiome and Its Fibre Fermentative Capacity in Adults with Inflammatory Bowel Disease in Remission Microbiome Gerasimidis, K Despite extensive microbial dysbiosis, patients with IBD have a similar capacity to ferment fibre and release SCFA as HC. Fibre supplementation alone may be unlikely to restore to a healthy status the compositional shifts characteristic of the IBD microbiome. Nutrients 2022, 14(5), 1053;
Jan 2022 Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study Microbiome Olendzki, B In conclusion, we demonstrate that the IBD-AID can favor bacteria commonly depleted in IBD patients which are key for maintaining immune tolerance and homeostasis in the gut via SCFA production. We demonstrated that foods encouraged/discouraged by the IBD-AID are linked to modulation of the immune tone. Gut Microbes. 2022 Jan-Dec;14(1):2046244. doi: 10.1080/19490976.2022.2046244.
Jul 2021 The Role of Precision Nutrition in the Modulation of Microbial Composition and Function in People with Inflammatory Bowel Disease Microbiome Sasson AN, Ingram RJM, et al Authors discuss dietary patterns and their influence on the structure and function of the gut microbiome. They also discuss potential of innovative dietary strategies and future development of precision nutrition. Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00097-2. doi:10.1016/S2468-1253(21)00097-2
Jul 2021 Gut-Microbiota-Targeted Diets Modulate Human Immune Status Microbiome Wastyk H et al Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit. Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019
Jul 2021 Long-term Dietary Patterns are Associated with Pro-Inflammatory and Anti-Inflammatory Features of the Gut Microbiome Microbiome Bolte L et al Authors identify dietary patterns that consistently correlate with groups of bacteria with shared functional roles in health and disease. Specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects, proposing a microbial mechanism for anti-inflammatory dietary effects Gut. 2021;70(7):1287-1298. doi:10.1136/gutjnl-2020-322670
Mar 2021 Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome Microbiome Fitzgerald RS et al In this review, the authors look at the increasing number of studies investigating the role the microbiome and other biomes play in pediatric patients with IBD, particularly changes associated with IBD, varying disease states, and therapeutics. Fitzgerald, R.S., Sanderson, I.R. & Claesson, M.J. Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome. Microb Ecol (2021).

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