Related Research

To Fiber or Not to Fiber: The Swinging Pendulum of Fiber Supplementation in Patients with Inflammatory Bowel Disease

This review describes dietary fibers and their mechanism of action within the microbiome, details novel fiber sources, including resistant starches and polyphenols, and concludes with potential future directions in fiber research, including the move toward precision nutrition.

Nutrients 2023, 15(5), 1080; https://doi.org/10.3390/nu15051080

Authors: Haskey N. et al.

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P380 Changes in faecal microbiome and metabolome are more pronounced in Crohn’s disease patients who adhered to the CD-TREAT diet and responded by calprotectin.

Treatment with the CD-TREAT solid food diet improves disease activity indices, faecal calprotectin (FCAL) levels and quality of life in adults and children with active Crohn’s disease (CD); particularly in patients who adhere to the diet. Here we describe changes in faecal microbiome parameters during therapy with CD-TREAT and explore these changes against adherence.

Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i513–i515, https://doi.org/10.1093/ecco-jcc/jjac190.0510

Authors: Svolos V., et al.

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Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study

Pilot data indicate that promotion of both zinc intake and a Japanese diet rich in n-3 fatty acids may help induce clinical remission in patients with mild active UC. Nonetheless, large-scale randomized controlled trials are required to validate our findings.

Journal of Clinical Biochemistry and Nutrition, 2023, Volume 72, Issue 1, Pages 82-88,

Authors: Miyaguchi, K. et al.

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Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients

Inflammatory bowel diseases are overall beneficially impacted by dietary fibers that are fermented by colonic microbes. Unfermented dietary β-fructan fibers induced proinflammatory cytokines in a subset of inflammatory bowel disease patient samples, via activation of the NLRP3 and TLR2 pathways; inflammation was reduced via fermentation by microbes.

Gastroenterology, 2023. https://doi.org/10.1053/j.gastro.2022.09.034

Authors: Armstrong H. et al.

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Photo Credit: Kolpakova Svetlana/Shutterstock 

The Effects of Commonly Consumed Dietary Fibres on the Gut Microbiome and Its Fibre Fermentative Capacity in Adults with Inflammatory Bowel Disease in Remission

Despite extensive microbial dysbiosis, patients with IBD have a similar capacity to ferment fibre and release SCFA as HC. Fibre supplementation alone may be unlikely to restore to a healthy status the compositional shifts characteristic of the IBD microbiome.

Nutrients 2022, 14(5), 1053; https://doi.org/10.3390/nu14051053

Authors: Gerasimidis, K

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Photo Credit: Apichatn21/Shutterstock 

Dietary manipulation of the gut microbiome in inflammatory bowel disease patients: Pilot study

In conclusion, we demonstrate that the IBD-AID can favor bacteria commonly depleted in IBD patients which are key for maintaining immune tolerance and homeostasis in the gut via SCFA production. We demonstrated that foods encouraged/discouraged by the IBD-AID are linked to modulation of the immune tone.

Gut Microbes. 2022 Jan-Dec;14(1):2046244. doi: 10.1080/19490976.2022.2046244.

Authors: Olendzki, B

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The Role of Precision Nutrition in the Modulation of Microbial Composition and Function in People with Inflammatory Bowel Disease

Authors discuss dietary patterns and their influence on the structure and function of the gut microbiome. They also discuss potential of innovative dietary strategies and future development of precision nutrition.

Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00097-2. doi:10.1016/S2468-1253(21)00097-2

Authors: Sasson AN, Ingram RJM, et al

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Gut-Microbiota-Targeted Diets Modulate Human Immune Status

Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit.

Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019

Authors: Wastyk H et al

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Long-term Dietary Patterns are Associated with Pro-Inflammatory and Anti-Inflammatory Features of the Gut Microbiome

Authors identify dietary patterns that consistently correlate with groups of bacteria with shared functional roles in health and disease. Specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects, proposing a microbial mechanism for anti-inflammatory dietary effects

Gut. 2021;70(7):1287-1298. doi:10.1136/gutjnl-2020-322670

Authors: Bolte L et al

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Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome

In this review, the authors look at the increasing number of studies investigating the role the microbiome and other biomes play in pediatric patients with IBD, particularly changes associated with IBD, varying disease states, and therapeutics.

Fitzgerald, R.S., Sanderson, I.R. & Claesson, M.J. Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome. Microb Ecol (2021). https://doi.org/10.1007/s00248-021-01697-9

Authors: Fitzgerald RS et al

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Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os

Here, we review the literature for dietary considerations during hospitalizations and acute settings, as well as upon discharge. Patients with IBD benefit from screening and nutritional support for malnutrition and nutritional deficiencies. Enteral nutrition and exclusion diets are promising as induction and maintenance therapies, but no specific recommendations during hospitalization for adult patients are available currently. There are very few reasons to enforce bowel rest or clear liquids other than bowel obstruction, uncontrolled sepsis, or need for urgent or emergent surgery; most patients—including many with penetrating or stricturing disease—benefit from feeding in whichever capacity is tolerated, with enteral and parenteral nutrition used as needed to reach nutritional goals.

Crohn's & Colitis 360, Volume 2, Issue 4, October 2020, otaa059

Authors: Palchaudhuri S et al

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Perioperative Dietary Therapy in Inflammatory Bowel Disease

Perioperative dietary therapy improves the outcomes of IBD patients who undergo a surgical procedure. This topical review shares interdisciplinary expertise and provides guidance to optimise the outcomes of patients with Crohn's disease and ulcerative colitis. taking advantage of contemporary nutrition science.

J Crohns Colitis . 2020 May 21;14(4):431-444. doi: 10.1093/ecco-jcc/jjz160.

Authors: Adamina M et al

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