Related Research

The Role of Precision Nutrition in the Modulation of Microbial Composition and Function in People with Inflammatory Bowel Disease

Authors discuss dietary patterns and their influence on the structure and function of the gut microbiome. They also discuss potential of innovative dietary strategies and future development of precision nutrition.

Lancet Gastroenterol Hepatol. 2021;S2468-1253(21)00097-2. doi:10.1016/S2468-1253(21)00097-2

Authors: Sasson AN et al

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Gut-Microbiota-Targeted Diets Modulate Human Immune Status

Two microbiota targeted interventions, plant based fiber and fermented foods, influence the human microbiome and immune system, whereby coupling them may provide longitudinal benefit.

Cell. 2021;S0092-8674(21)00754-6. doi:10.1016/j.cell.2021.06.019

Authors: Wastyk H et al

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Long-term Dietary Patterns are Associated with Pro-Inflammatory and Anti-Inflammatory Features of the Gut Microbiome

Authors identify dietary patterns that consistently correlate with groups of bacteria with shared functional roles in health and disease. Specific foods and nutrients were associated with species known to infer mucosal protection and anti-inflammatory effects, proposing a microbial mechanism for anti-inflammatory dietary effects

Gut. 2021;70(7):1287-1298. doi:10.1136/gutjnl-2020-322670

Authors: Bolte L et al

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Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome

In this review, the authors look at the increasing number of studies investigating the role the microbiome and other biomes play in pediatric patients with IBD, particularly changes associated with IBD, varying disease states, and therapeutics.

Fitzgerald, R.S., Sanderson, I.R. & Claesson, M.J. Paediatric Inflammatory Bowel Disease and its Relationship with the Microbiome. Microb Ecol (2021). https://doi.org/10.1007/s00248-021-01697-9

Authors: Fitzgerald RS et al

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Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os

Here, we review the literature for dietary considerations during hospitalizations and acute settings, as well as upon discharge. Patients with IBD benefit from screening and nutritional support for malnutrition and nutritional deficiencies. Enteral nutrition and exclusion diets are promising as induction and maintenance therapies, but no specific recommendations during hospitalization for adult patients are available currently. There are very few reasons to enforce bowel rest or clear liquids other than bowel obstruction, uncontrolled sepsis, or need for urgent or emergent surgery; most patients—including many with penetrating or stricturing disease—benefit from feeding in whichever capacity is tolerated, with enteral and parenteral nutrition used as needed to reach nutritional goals.

Crohn's & Colitis 360, Volume 2, Issue 4, October 2020, otaa059

Authors: Palchaudhuri S et al

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Perioperative Dietary Therapy in Inflammatory Bowel Disease

Perioperative dietary therapy improves the outcomes of IBD patients who undergo a surgical procedure. This topical review shares interdisciplinary expertise and provides guidance to optimise the outcomes of patients with Crohn's disease and ulcerative colitis. taking advantage of contemporary nutrition science.

J Crohns Colitis . 2020 May 21;14(4):431-444. doi: 10.1093/ecco-jcc/jjz160.

Authors: Adamina M et al

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Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis

In a cross-over study of patients with UC in remission, we found that a catered LFD or iSAD were each well tolerated and increased quality of life. However, the LFD decreased markers of inflammation and reduced intestinal dysbiosis in fecal samples. Dietary interventions therefore might benefit patients with UC in remission.

Clin Gastroenterol Hepatol . 2020 May 20;S1542-3565(20)30685-6. doi: 10.1016/j.cgh.2020.05.026

Authors: Fritsch J et al

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The microbiome and inflammatory bowel disease

In this review we will discuss the role of the gut microbiome in patients with IBD; our focus will be on human studies.

J Allergy Clin Immunol Pract. 2020 Jan;145(1)16-27. doi:10.1016/j.jaci.2019.11.003

Authors: Glassner KL et al

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A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares

In an analysis of data from the FACES trial, we found that among patients with CD in remission, level of red and processed meat consumption was not associated with time to symptomatic relapse.

Gastroenterology . 2019 Jul;157(1):128-136.e5. doi: 10.1053/j.gastro.2019.03.015. Epub 2019 Mar 11.

Authors: Albenberg L et al

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Gut Microbiome Structure and Metabolic Activity in Inflammatory Bowel Disease

Our findings thus provide an improved understanding of perturbations of the microbiome-metabolome interface in IBD, including identification of many potential diagnostic and therapeutic targets.

Nat Microbiol . 2019 Feb;4(2):293-305. doi: 10.1038/s41564-018-0306-4. Epub 2018 Dec 10.

Authors: Franzosa EA et al

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Diet, Gut Microbiome and Epigenetics: Emerging Links With Inflammatory Bowel Diseases and Prospects for Management and Prevention

Other nutritional interventions or specific diets including the Specific Carbohydrate Diet (SCD), the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diet and, most recently, the Mediterranean diet have shown strong anti-inflammatory properties and show promise for improving disease symptoms. More work is required to evaluate the role of individual food compounds and complex nutritional interventions with the potential to decrease inflammation as a means of prevention and management of IBD.

Nutrients , 9 (9) 2017 Aug 30

Authors: Aleksandrova K et al

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The Microbiota in Inflammatory Bowel Disease: Current and Therapeutic Insights

This review will characterize the factors involved in the development of the intestinal microbiome and will describe the typical alterations in the microbiota that are characteristic of inflammatory bowel disease. Additionally, this manuscript will summarize the early but promising literature on the role of the gut microbiota in the pathogenesis of inflammatory bowel disease with implications for utilizing this data for diagnostic or therapeutic application in the clinical management of patients with these diseases.

J Inflamm Res , 10, 63-73 2017 Jun 10 eCollection 2017

Authors: Lane ER et al

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