Randomised Clinical Trial: Exclusive Enteral Nutrition Versus Standard of Care for Acute Severe Ulcerative Colitis
Abstract
Sahu, P., Kedia, S., Vuyyuru, S. K., Bajaj, A., Markandey, M., Singh, N., Singh, M., Kante, B., Kumar, P., Ranjan, M., Sahni, P., Panwar, R., Sharma, R., Das, P., Makharia, G., Travis, S. P. L., & Ahuja, V. (2021). Randomised clinical trial: exclusive enteral nutrition versus standard of care for acute severe ulcerative colitis. Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/apt.16249
Patients on EEN had a shorter hospital stay [median (range) 10 (8-17) vs 13 (8-24) days; P = 0.04], higher day 7 albumin level (34 ± 4 vs 29 ± 3 g/L, P < 0.01), greater reduction in serum C-reactive protein and faecal calprotectin levels (both P = 0.04) and a lower composite outcome of colectomy/hospitalisation at 6 months (16% vs 39%; P = 0.045) compared to SOC.
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