Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease
Abstract
Yang, Z., Qin, J., Zhao, L., Chen, T., Huang, Q., Jian, Y., Zhao, Q., Yang, S., Li, Q., Liu, Q., Otto, M., & Li, M. (2023). Host Sorbitol and Bacterial Sorbitol Utilization Promote Clostridioides difficile Infection in Inflammatory Bowel Disease. Gastroenterology, 164(7), 1189-1201.e13. https://doi.org/10.1053/j.gastro.2023.02.046
Sorbitol and sorbitol utilization in the infecting C difficile strain play major roles for the pathogenesis and epidemiology of CDI in patients with IBD. CDI in patients with IBD may thus be avoided or improved by elimination of dietary sorbitol or suppression of host-derived sorbitol production.
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